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What is Apligraf®?What is Apligraf®?How is Apligraf® Applied?

Healing wounds as quickly as possible
Apligraf® is a living product that must be ordered by your doctor. It may be applied in a hospital, in a Wound Care Center (a medical center specializing in treating non-healing wounds) or in your doctor’s office.

First, your doctor prepares your ulcer for Apligraf® by cleaning it and possibly debriding it (debridement is a treatment involving the removal of dead, damaged or infected tissue from a wound). Then Apligraf® is placed directly on the wound. The wound is then covered with a non-adhesive dressing to keep Apligraf® in place. The area is then wrapped with other dressings that are changed weekly by the doctor or nurse. The healing process now begins, and improvement of the wound can usually be seen within weeks.

A Wound Care Center is the best place to get treated for your ulcer, and to find Apligraf®. To find a Wound Care Center near you, click here.


How is Apligraf® applied?

Apligraf® is placed directly on wound step_1
Apligraf® is covered with non-adherent dressing step 2
The area is then wrapped with final dressings step 3


1. Falanga V, Sabolinski ML. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201-207.

2. Ramsey SD, Newton K, Blough D, et al. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999;22:382-387.

Appligraf® heals more sores.With Apligraf® Improvement is withing weeks.