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What is Apligraf®?How Apligraf® WorksHow Apligraf® Works
Clinical Experience

Wounds treated by Apligraf®
Apligraf® was developed and is manufactured by Organogenesis, one of the world’s first regenerative medicine companies, and the world’s most important tissue regeneration company. Apligraf® has been used worldwide to heal ulcers for over 10 years. Apligraf® is the first living, cell-based tissue regeneration product, having gained the Food and Drug Administration’s approval in 1998.

Proven results
In studies, Apligraf® has been proven to heal chronic wounds significantly faster than standard wound care; moist dressing, compression therapy, debridement (debridement is a treatment involving the removal of dead, damaged or infected tissue from a wound), off-loading and compression therapy. Clinical trials have also shown that Apligraf® can help close many severe wounds that have been resistant to standard therapy. Apligraf® is safe and well tolerated, with no major reported side effects.2,3

A history of healing
Click here to see some examples of venous leg ulcers and diabetic foot ulcers that were treated with Apligraf®

Diabetic Foot Ulcer Treated with Apligraf®
Venous Leg Ulcer Treated with Apligraf®


2. Ramsey SD, Newton K, Blough D, et al. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999;22:382-387.

3. Falanga V, Sabolinski ML. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201-207.

4. Veves A, Falanga V, et al. Graftskin, a human skin equivalent, is effective in management of non-infected neuropathic diabetic foot ulcers. Diabetes Care. 2001;24:290-295