A unique living-cell based therapy available to treat non-healing sores
For patients with diabetic foot sores or venous leg sores, Apligraf® is an advanced biological skin repair therapy, providing hope for healing some of the most persistent non-healing sores.

Apligraf® is a unique biological product, containing living cells and structural (rebuilding) proteins and growth factors similar to healthy human skin. Because it is biological, the body can use the elements in Apligraf® to help repair itself. As a result, Apligraf® is natural and well tolerated, with no major reported side effects.

When healthy skin gets wounded or damaged, the proteins, cells and growth factors in the skin tell the body to rebuild and regrow new skin. This is the normal wound healing process. However, with certain diseases such as diabetes and problems with circulation, these cells, proteins and growth factors do not work properly, and the healing cycle, including skin regrowth, is broken. This can result in a sore.

Apligraf® contains key ingredients (fresh cells, nutrients and proteins) for natural, biological wound healing. Apligraf® is designed to deliver these key ingredients on an ongoing basis as the wound heals.
 
The active wound healing advantage
Many wound therapies (dressings, antibiotics and antiseptics) are designed to passively manage the wound. Apligraf® plays a more active role in stimulating the skin to repair and heal itself.  Apligraf® delivers ingredients such as growth factors, cells, proteins to the wound directly.