Apligraf® is a unique biological product, containing the same living cells and structural (rebuilding) proteins and growth factors as healthy human skin. Because it is biological, the body can use the elements in Apligraf® to help repair itself. As a result, Apligraf® is natural and well tolerated, with no major reported side effects.

Apligraf® application is painless.

Safety information for diabetic foot sore:
Over 150,000 patients have been treated with Apligraf®

Your doctor should not apply Apligraf® if the wound is infected or if you have an allergy to bovine collagen or any of the components in the Apligraf®* shipping gel. Although in clinical studies of more than 1,000 patients, no allergic reactions have been reported, you should notify your physician if you have any allergy symptoms.

In a study of patients treated with Apligraf®, the most common health problems were related to an open sore, the skin, or diabetes. These potential problems were generally temporary or treatable by a doctor and similar to those found in patients treated with moist gauze or removal of weight from the foot.

The most common health problems experienced were a new foot ulcer, suspected wound infection, a skin tear or cut, skin inflammation, bone infection, rash pain, low blood sugar or high blood sugar, non-wound infection, bruising, swelling, worsening ulcer, and dry skin.

Some patients experienced other health problems not associated with the skin or their diabetes, the incidences of which were similar between patients receiving Apligraf® or those treated with moist gauze and removal of weight from the foot.

While the safety of Apligraf® has not been studied beyond 6 months, Apligraf® has an established safety profile in over 150,000 patients during the last 10 years. Patients treated with Apligraf® have shown no increased risk of developing cancer; however, the long-term possibility has not been evaluated.

* Contains agarose, L-glutamine, hydrocortisone/bovine serum albumin, bovine insulin, human transferrin, triiodothyronine, ethanolamine, O-phosphoryl-ethanolamine, adenine, selenious acid, DMEM powder, and HAM’s F-12 powder.

Link to prescribing information

Safety information for venous leg sore:
Over 150,000 patients have been treated with Apligraf®

Your doctor should not apply Apligraf® if the wound is infected or if you have an allergy to bovine collagen or any of the components in the Apligraf®* shipping gel. Although in clinical studies of more than 1,000 patients no allergic reactions have been reported, you should notify your physician if you have any allergy symptoms.

In a study of patients treated with Apligraf®, the most common health problems were related to an open sore or the skin. These potential problems were generally temporary or treatable by a doctor and similar to those found in patients treated with compression therapy.

The most common health problems experienced were suspected wound infection, skin inflammation, wound drainage, swelling, a skin tear or cut, pain, new ulcer, and red flaky skin. Suspected wound infection was more common in patients receiving Apligraf®. Some patients experienced other health problems not associated with the skin, the incidences of which were similar between patients receiving Apligraf® or compression therapy.

While the safety of Apligraf® has not been studied beyond one year, Apligraf® has an established safety profile in over 150,000 patients during the last 10 years. Patients treated with Apligraf® have shown no increased risk of developing cancer; however, the long-term possibility has not been evaluated.

* Contains agarose, L-glutamine, hydrocortisone/human recombinant insulin, DMEM, HAM’s F-12, Calcium Chloride, Sodium Bicarbonate, Adenine, Selenious Acid, Ethanolamin O-phos-ethanolamine (AKA EOP) and water.

Link to prescribing information