Apligraf® is a unique, advanced biological skin repair therapy, and is created from biological ingredients found in healthy human skin. Which explains why it looks like a thin, circular piece of real skin.

It is used to heal sores such as diabetic foot and venous leg ulcers that are not healing after 3-4 weeks, despite treatment with conventional therapies.

When healthy skin gets wounded, the proteins and growth factors in the skin stimulate the body to regenerate new skin. This is the normal wound healing process.1 
However with certain diseases (like diabetes and circulatory problems), the skin is missing these biological substances, and the healing cycle is broken. This leads to the development of non-healing ulcers and sores.2,3

Much like your own skin, Apligraf® contains two types of cells – an outer layer of protective skin cells, and an inner layer of cells, both of which contain key healing substances. Apligraf® does not contain certain things in skin such as hair follicles, sweat glands or blood vessels.

Apligraf® is able to help heal and repair chronic sores and regenerate your skin by stimulating the body’s natural healing process. It delivers these biological healing substances (fresh cells, nutrients and proteins) directly into the wound, and thus naturally kick starts the healing cycle.

How is Apligraf® different from other wound therapies?

Apligraf® is different because it is NOT a cream, ointment, or traditional wound dressing. It is a biological tissue regeneration therapy made to treat non-healing sores and wounds.

Apligraf® is placed directly on the wound.
The wound is then covered with a non-adhesive dressing to keep it moist and to keep Apligraf® in place. The area is then wrapped with other dressings that are changed weekly by the doctor or nurse. The healing process now begins, and improvement of the wound can usually be seen within weeks.
Many wound therapies, like dressings and antibacterial treatments, are designed to manage a sore until the body heals itself. Apligraf® plays a more active and biological role in stimulating the skin to repair and heal itself. Apligraf® delivers ingredients such as growth factors, cells, nutrients and proteins to the wound directly. And because it is biological, it is natural and well tolerated, with no major reported side effects.

Apligraf® is a prescription product that must be applied by a medical professional. It is not available in pharmacies nor can it be purchased online. To use our locator to find a Wound Care Center with Apligraf® experience nearest you, click here.

         Which Wounds Does Apligraf® Treat?

         Learn about Diabetic Foot Sores

         Learn about Venous Leg Sores

         How Apligraf® Works

         The Science behind Apligraf®

         Clinical Experience

How does Apligraf® Compare?

How is Apligraf® Applied?

After Care/ What to Expect?

Safety Information