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What is Apligraf®?What is Apligraf®?What Wounds Does Apligraf® Treat?

Hope for healing even the most stubborn wounds

Diabetes and problems with circulation can interrupt the skin healing cycle, which in turn can cause non-healing wounds and ulcers to develop and linger on.

The two types of non-healing wounds treated by Apligraf® are called diabetic foot ulcers and venous leg ulcers. Even if it doesn’t hurt, an open wound is a medical emergency. It can lead to life threatening infection, gangrene and, in the case of diabetic foot ulcers, amputation. Venous leg ulcers can also lead to severe pain. 

A non-healing wound is one that is not healing after 3-4 weeks. It may require special medical attention because this kind of wound will not always respond to standard treatments like antibiotics, creams, dressings and debridement (a treatment involving the removal of dead, damaged or infected tissue from a wound).

Beyond being uncomfortable and inconvenient, these types of open wounds can seriously impact your quality of life. A stubborn ulcer can limit your mobility, your day-to-day activities, your independence, and affect your self-esteem.1

Learn about Diabetic Foot Ulcer

Learn about Venous Leg Ulcer


1. Phillips T, Stanton B, Provan A, et al. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol. 1994;31:49-53.

2. Capeheart JK. Chronic venous insufficiency: a focus on prevention of venous ulceration. J Wound Ostomy Continence Nurs. 1996;23:227-234.

3. Falanga V, Sabolinski ML. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201-207.

4. Veves A, Falanga V, et al. Graftskin, a human skin equivalent, is effective in management of non-infected neuropathic diabetic foot ulcers. Diabetes Care.