Apligraf Case Study – Recalcitrant Venous Ulcer
Patient: 78-year-old female
Wound: Venous leg ulcer of 2 years duration; baseline wound area at presentation measured 8.4 cm²
Prior Treatment: Compression; autologous platelet-derived wound healing formula (Procuren®); hyperbaric oxygen
Apligraf Application: Apligraf was applied and the wound was dressed with nonadherent dressing and elastic wrap(Coban™).
The case presented here represents the experience of a single patient and may not be typical of all patients. Apligraf® should not be used on infected wounds or on patients with known hypersensitivities to any components of Apligraf. Please consult the complete prescribing information for a description of epidermal and dermal elements contained in Apligraf.
Week 3
Noticeable formation of granulation tissue and new tissue at periphery. The area of the wound has decreased in size as wound edge migrates inward.
Week 7
Marked reduction in size and depth of ulcer.
Week 13
Healing process nears completion.
Week 22
Full wound closure and physiologic repair (week 9 of follow-up).