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Safety Considerations

The wound bed should be thoroughly cleansed with saline before applying Apligraf.

Apligraf should not be applied over infected wounds. It is contraindicated in patients with known allergies to bovine collagen or known hypersensitivity to the components of the Apligraf Agarose shipping material.

To minimize the risk of infection, antimicrobial agents may be used the week prior to Apligraf. However, Dakin's solution, mafenide acetate, scarlet red dressing, Tincoban, zinc sulfate, povidone-iodine solution, and chlorhexidine have been determined to be cytotoxic to Apligraf and should not be used immediately prior to or after Apligraf application.

Apligraf has been well-tolerated in over 150,000 patient applications.

Contraindications

Apligraf should not be used on infected wounds, or on patients with known allergies to bovine collagen or hypersensitivity to the components of the shipping medium. Please refer to complete prescribing information for a complete description of Apligraf and its components.