We use cookies to make it easier for you to use our website and give you a better experience. We aggregate the information we get through cookies from users like you, and analyze that data to better understand user behavior and help us improve the website. We do not give or sell the data you provide through cookies to any third party for any purpose (such as advertising or marketing). By using this website, you consent to Organogenesis using cookies for these purposes. You may change your settings anytime by clicking on the “Security” tab on your browser. Note that Organogenesis is located in the United States, and the U.S. has not yet been determined to have “adequate” data privacy safeguards by the EU; despite any inherent risks in the transfer of data from the EU, Organogenesis takes the security of your information seriously. To read our privacy policy, click here.

Safety Considerations

The wound bed should be thoroughly cleansed with saline before applying Apligraf.

Apligraf should not be applied over infected wounds. It is contraindicated in patients with known allergies to bovine collagen or known hypersensitivity to the components of the Apligraf Agarose shipping material.

To minimize the risk of infection, antimicrobial agents may be used the week prior to Apligraf. However, Dakin's solution, mafenide acetate, scarlet red dressing, Tincoban, zinc sulfate, povidone-iodine solution, and chlorhexidine have been determined to be cytotoxic to Apligraf and should not be used immediately prior to or after Apligraf application.

Apligraf has been well-tolerated in over 150,000 patient applications.


Apligraf should not be used on infected wounds, or on patients with known allergies to bovine collagen or hypersensitivity to the components of the shipping medium. Please refer to complete prescribing information for a complete description of Apligraf and its components.